For research use only. Not for human or veterinary use. Not for diagnostic or therapeutic use.
Menu
Reconstitution calculator

Dermal biology research

GHK-Cu Dosage, Protocol & Research Guide

By Sam, MBA

  • MW 402.92 g/mol
  • CAS 89030-95-5
Dosage, protocol, reconstitution and storage reference for GHK-Cu, with a reconstitution calculator, vial sizes and cited research.

Reconstitution calculator

Sizes in the Pepcore catalogue50 mg100 mg

Calculator example, not a recommended amount

Concentration
25 mg/mL
Volume to draw
0.01 mL
Units on a U-100 syringe
1 units

0102030405060708090100

Properties

CAS
89030-95-5
Molecular weight
402.92 g/mol
Formula
Not yet recorded
Sequence
GHK (Gly-His-Lys), Cu(II) complex
Aliases
Copper peptide, Copper tripeptide-1, Prezatide copper, GHK copper
Vial sizes (mg)
10, 50, 100

Storage

Lyophilised (dry powder)

-20 °C; supplied as a solid (Cayman Chemical GHK-Cu (acetate), item 28259).[4]

Source

Storage notes

Lyophilized
Not yet recorded from a cited source
Reconstituted stability (days)
Not yet recorded from a cited source

Side effects, contraindications and regulatory status

Reported side effects

  • FDA safety-risk page (current as of 2026-04-22): compounded injectable drugs containing GHK-Cu may pose risk for immunogenicity (aggregation, peptide-related impurities); FDA notes limited data in humans on injectable routes.[5] Regulator or expert-panel statement
  • Topical cosmetic use only: the Cosmetic Ingredient Review Expert Panel (Int J Toxicol 2018) reports Copper Tripeptide-1 use typically below 10 ppm and concludes these ingredients are safe in cosmetics as used (cosmetic products only; injected use was not assessed).[6] Regulator or expert-panel statement
  • Evidence-mapping review (Pharmaceutics 2026): clinical evidence for GHK-Cu remains sparse; the authors note literature often ignores formulation-dependent variation in stability, pharmacokinetics and toxicity.[7] Observational
  • Narrative review (Sports Med 2026) covering GHK-Cu, BPC-157, thymosin beta-4 and TB-500 among others: the authors state rigorous human safety data are scarce for many unapproved peptides.[8] Observational

Cautions from reviews and trials

  • Review cautions: the 2026 Am J Sports Med scoping review (GHK-Cu, BPC-157, thymosin beta-4 or TB-500 and others) says these peptide supplements should not currently be recommended as a replacement or adjunct for existing orthopaedic standard of care.[9] Observational

Regulatory status

FDA 503A categories list (updated 2026-05-14): GHK-Cu except for injectable routes is in category 1 (under evaluation); FDA plans to consult its advisory committee by end Feb 2027. Checked 2026-10-20.[1] Source

Report any adverse reaction to a qualified healthcare professional.

What the research says

Summaries of the cited studies, each with its evidence grade.

  • Randomized trial, 13 completers (Arch Facial Plast Surg 2006)[2]

    Human trial human

    Randomized trial, 13 completers (Arch Facial Plast Surg 2006): skin care regimen with or without topical GHK-Cu after CO2 laser resurfacing of the circumoral skin, assessed through 12 weeks; amount per application not stated in the abstract

    Human clinical trial

  • Otolaryngol Head Neck Surg 2013 (doi 10.1177/0194599813492644)[3]

    Animal study Animal data rat (Sprague-Dawley, irradiated dorsal flap)

    Otolaryngol Head Neck Surg 2013 (doi 10.1177/0194599813492644): topical GHK-Cu gel or aquaphilic ointment control applied twice daily for 10 days; amount per application not stated in the abstract

    Animal or in-vitro study

Compare vial sizes

Compare vial sizes
SizePriceDoses available from the vial CalculatedCost per dose Calculated
50 mg$17.99——
100 mg$34.99——

Cost per dose uses the listed partner price and the reference dose cited on this page. Prices change; check the product page.

Calculated from a default of 2 mL water (adjustable).

PeptideCheck may earn a commission when you use Pepcore links, at no extra cost to you. Read the disclosure.

Frequently asked questions

How is lyophilised GHK-Cu stored?

Cited storage for the lyophilised vial: -20 °C; supplied as a solid (Cayman Chemical GHK-Cu (acetate), item 28259)..

What is the regulatory status of GHK-Cu?

FDA 503A categories list (updated 2026-05-14): GHK-Cu except for injectable routes is in category 1 (under evaluation); FDA plans to consult its advisory committee by end Feb 2027. Checked 2026-10-20.

Compound facts

Recorded molecular weight: 402.92 g/mol.
Recorded CAS number: 89030-95-5
Not yet recorded from a cited source.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/71587328
PubMed IDs
29986520, 22666519

References

Numbered sources used on this page. Markers in the text link here.

  1. fda.gov
  2. Randomized trial, 13 completers (Arch Facial Plast Surg 2006) pubmed.ncbi.nlm.nih.gov Human trial
  3. Otolaryngol Head Neck Surg 2013 (doi 10.1177/0194599813492644) pubmed.ncbi.nlm.nih.gov Animal study
  4. caymanchem.com Manufacturer documentation
  5. fda.gov Regulator or expert-panel statement
  6. pure.psu.edu Regulator or expert-panel statement
  7. pubmed.ncbi.nlm.nih.gov Observational
  8. pubmed.ncbi.nlm.nih.gov Observational
  9. pubmed.ncbi.nlm.nih.gov Observational

Vial sizes and protocols

  • 50 mgPartner size

  • 100 mgPartner size

Available from Pepcore

Supplied as research material for laboratory use only.

PeptideCheck may earn a commission when you use Pepcore links, at no extra cost to you. Read the disclosure.