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Metabolic receptor research

MOTS-c Dosage, Protocol & Research Guide

By Sam, MBA

  • MW 2,174.6 g/mol
  • CAS 1627580-64-6
Dosage, protocol, reconstitution and storage reference for MOTS-c, with a reconstitution calculator, vial sizes and cited research.

Dose overview

Every range below is taken from the cited source and carries its evidence grade.

No human dose-finding trial is cited on this page.

Animal data (context only, not a human dose)

Animal figures are shown for context and are never presented as a human dose. Use the converter to see how animal figures scale.

Animal data (context only, not a human dose)
SourceSpeciesDoseFrequencyRouteDurationEvidence
Lee et al., Cell Metab 2015 (doi 10.1016/j.cmet.2015.02.009)[2]MOTS-c 0.5 mg/kg/day intraperitoneally for 3 weeks (8 weeks in the obesity experiment) in CD-1 mice on a high-fat diet; 5 mg/kg/day intraperitoneally for 7 days in C57BL/6 mice in other experimentsmouse (CD-1, C57BL/6)0.5–5 mg/kg[2]intraperitoneal; 0.5 mg/kg/day in CD-1 mice on a high-fat diet (3 weeks in the energy-expenditure experiment, 8 weeks in the obesity experiment); 5 mg/kg/day in C57BL/6 mice for 7 days; the two amounts are separate experiments, not a titrationdailyother— Animal or in-vitro study

Evidence grades: A approved label, B human trial, C observational, D animal study, E community-reported.

Reconstitution calculator

Sizes in the Pepcore catalogue10 mg

Calculator example, not a recommended amount

Concentration
5 mg/mL
Volume to draw
0.05 mL
Units on a U-100 syringe
5 units

0102030405060708090100

Properties

CAS
1627580-64-6
Molecular weight
2,174.6 g/mol
Formula
Not yet recorded
Sequence
MRWQEMGYIFYPRKLR
Aliases
Not yet recorded
Vial sizes (mg)
5, 10, 40

Study duration

3 weeks[2] Animal study

Duration of the cited study. It describes the source and is not a recommended cycle; no off period is stated. Source

Storage

Lyophilised (dry powder)

-20 °C; supplied as a solid (Cayman Chemical MOTS-c (human) trifluoroacetate salt, item 29785).[3]

Source

Storage notes

Lyophilized
Not yet recorded from a cited source
Reconstituted stability (days)
Not yet recorded from a cited source

Side effects, contraindications and regulatory status

Reported side effects

  • FDA evaluation of MOTS-c-related bulk drug substances (briefing document dated 2026-05-11): FDA did not identify human exposure data, pharmacokinetic data, or clinical studies of MOTS-c administered to humans.[4] Regulator or expert-panel statement
  • Same FDA document: FDA is concerned about immunogenicity of a 16-amino-acid peptide given by injection, from aggregation and peptide-related impurities, and finds insufficient data to conclude these risks are absent.[4] Regulator or expert-panel statement
  • FDA safety-risk page (current 2026-04-22): compounded drugs containing MOTs-C may pose significant risk for immunogenicity for certain routes of administration.[1] Regulator or expert-panel statement
  • Narrative review (Sports Med 2026) covering MOTS-C among other unapproved peptides: many show favourable outcomes in animal models, but rigorous human safety data are scarce and there is potential for serious harm.[5] Observational

Regulatory status

Listed in the 'nominated but withdrawn' table of the FDA bulk-substance safety-risk page (current 2026-04-22); FDA identified no human exposure data. Checked 2026-10-20.[1] Source

Report any adverse reaction to a qualified healthcare professional.

What the research says

Summaries of the cited studies, each with its evidence grade.

  • Lee et al., Cell Metab 2015 (doi 10.1016/j.cmet.2015.02.009)[2]

    Animal study Animal data mouse (CD-1, C57BL/6)

    Lee et al., Cell Metab 2015 (doi 10.1016/j.cmet.2015.02.009): MOTS-c 0.5 mg/kg/day intraperitoneally for 3 weeks (8 weeks in the obesity experiment) in CD-1 mice on a high-fat diet; 5 mg/kg/day intraperitoneally for 7 days in C57BL/6 mice in other experiments

    Animal or in-vitro study

Compare vial sizes

Compare vial sizes
SizePriceDoses available from the vial CalculatedCost per dose Calculated
10 mg$67.99——

Cost per dose uses the listed partner price and the reference dose cited on this page. Prices change; check the product page.

Calculated from a default of 2 mL water (adjustable).

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Frequently asked questions

Is there a human dose figure for MOTS-c on this page?

No human dose figure is cited on this page. The cited research is in animals (evidence grade D); it is shown separately and is not a human dose.

How is lyophilised MOTS-c stored?

Cited storage for the lyophilised vial: -20 °C; supplied as a solid (Cayman Chemical MOTS-c (human) trifluoroacetate salt, item 29785)..

What study duration is cited for MOTS-c?

The cited duration is 3 weeks, with no off period stated (Animal or in-vitro study). It describes the source, not a recommendation.

What is the regulatory status of MOTS-c?

Listed in the 'nominated but withdrawn' table of the FDA bulk-substance safety-risk page (current 2026-04-22); FDA identified no human exposure data. Checked 2026-10-20.

Compound facts

Recorded molecular weight: 2,174.6 g/mol.
Recorded CAS number: 1627580-64-6
Not yet recorded from a cited source.

Sources

https://pubchem.ncbi.nlm.nih.gov/compound/146675088
PubMed IDs
25738459

References

Numbered sources used on this page. Markers in the text link here.

  1. fda.gov Regulator or expert-panel statement
  2. Lee et al., Cell Metab 2015 (doi 10.1016/j.cmet.2015.02.009) pmc.ncbi.nlm.nih.gov Animal study
  3. caymanchem.com Manufacturer documentation
  4. fda.gov Regulator or expert-panel statement
  5. pubmed.ncbi.nlm.nih.gov Observational

Vial sizes and protocols

  • 10 mgPartner size

Available from Pepcore

Supplied as research material for laboratory use only.

PeptideCheck may earn a commission when you use Pepcore links, at no extra cost to you. Read the disclosure.