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HCG Dosage, Protocol & Research Guide
Label figures describe the approved branded products. The research materials listed on this page are not approved drugs and are not evaluated by any regulator.
Reconstitution calculator
Calculator example, not a recommended amount
- Concentration
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- Volume to draw
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- Units on a U-100 syringe
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Properties
- CAS
- Not yet recorded
- Molecular weight
- Not yet recorded
- Formula
- Not yet recorded
- Sequence
- Not yet recorded
- Aliases
- Human chorionic gonadotropin, Chorionic gonadotropin
- Vial sizes (mg)
- Not yet recorded
Storage notes
- Lyophilized
- Not yet recorded from a cited source
- Reconstituted stability (days)
- 60
Side effects, contraindications and regulatory status
Reported side effects
- Label statement (Novarel, urinary-derived hCG): hCG has not been demonstrated effective as adjunctive therapy in obesity; no substantial evidence it increases weight loss beyond caloric restriction; no known effect on fat mobilization or appetite.[1] Approved label
- Novarel label, Warnings (use with menotropins): ovarian hyperstimulation, enlargement or rupture of ovarian cysts with hemoperitoneum, multiple births and arterial thromboembolism are listed as the principal serious adverse reactions.[1] Approved label
- Pregnyl label, Warnings: ovarian hyperstimulation syndrome can progress rapidly and severe cases may be life-threatening; assess women for OHSS for at least two weeks after hCG administration; anaphylaxis reported with urinary-derived hCG.[2] Approved label
- Novarel label, Adverse Reactions: headache, irritability, restlessness, depression, fatigue, edema, precocious puberty, gynecomastia, injection site pain; localized and systemic hypersensitivity reactions have been reported.[1] Approved label
- Novarel label: sporadic reports of testicular tumors in healthy young men receiving hCG for secondary infertility; a causative relationship has not been established. Diluent benzyl alcohol is linked to fatal gasping syndrome in premature infants.[1] Approved label
Contraindications
- Novarel label: precocious puberty, prostatic carcinoma or other androgen-dependent neoplasm, prior allergic reaction to HCG; the label also states HCG may cause fetal harm when given to a pregnant woman.[1] Approved label
- Pregnyl label: prior hypersensitivity to human gonadotropins or excipients; high serum FSH (primary gonadal failure in women); uncontrolled non-gonadal endocrinopathies; abnormal vaginal bleeding of undetermined origin.[2] Approved label
- Pregnyl label: tumors of the hypothalamus or pituitary gland, and of ovary, breast or uterus in females and breast or prostate in males; malformations of reproductive organs or uterine fibroids incompatible with pregnancy.[2] Approved label
Regulatory status
US labels (DailyMed) for hCG products Novarel (Initial U.S. Approval 1974) and Pregnyl: Rx gonadotropin; label says not shown effective for obesity. Checked 2026-10-20.[1] Source
Report any adverse reaction to a qualified healthcare professional.
What the research says
Summaries of the cited studies, each with its evidence grade.
dailymed.nlm.nih.gov[1]
Novarel (urinary-derived hCG, Ferring) US label (DailyMed), intramuscular use only; label product, not a research peptide. Hypogonadotropic hypogonadism in males: 500 to 1,000 USP Units three times a week for three weeks, then the same dose twice a week for three weeks; or 4,000 USP Units three times weekly for 6 to 9 months, then may be reduced to 2,000 USP Units three times weekly for 3 months. Ovulation induction after menotropins: 5,000 to 10,000 USP Units one day after the last dose.
dailymed.nlm.nih.gov[2]
Pregnyl (urinary-derived hCG, Organon) US label (DailyMed), intramuscular use only; label product, not a research peptide. Same regimens as the Novarel label: hypogonadotropic hypogonadism in males 500 to 1000 USP units 3 times a week for 3 weeks, then twice a week for 3 weeks; ovulation induction 5000 to 10,000 USP units one day after the last gonadotropin dose.
Ovidrel (choriogonadotropin alfa, recombinant hCG, EMD Serono) US label (DailyMed)[3]
Ovidrel (choriogonadotropin alfa, recombinant hCG, EMD Serono) US label (DailyMed): a different product from urinary hCG; 250 mcg subcutaneously one day after the last dose of the follicle stimulating agent in ART or ovulation induction. Cited for identity only; no dose figure is attributed to hCG.
J Clin Endocrinol Metab 2005 (doi 10.1210/jc.2004-0802), randomized[4]
J Clin Endocrinol Metab 2005 (doi 10.1210/jc.2004-0802), randomized: men given testosterone enanthate 200 mg weekly plus hCG 0 (placebo), 125, 250 or 500 IU every other day for 3 weeks; intratesticular testosterone rose linearly with the hCG dose and stayed in the normal range at low doses
J Clin Endocrinol Metab 2010 (doi 10.1210/jc.2010-0360), randomized[5]
J Clin Endocrinol Metab 2010 (doi 10.1210/jc.2010-0360), randomized: after gonadotropin suppression with acyline, men received hCG 0, 15, 60 or 125 IU subcutaneously every other day for 10 days; intratesticular testosterone rose dose-dependently, from 77 nmol/l (0 IU) to 923 nmol/l (125 IU)
Compare vial sizes
| Size | Price | Doses available from the vial Calculated | Cost per dose Calculated |
|---|---|---|---|
| 5,000 IU | $68.99 | — | — |
| 10,000 IU | $82.99 | — | — |
Cost per dose uses the listed partner price and the reference dose cited on this page. Prices change; check the product page.
Calculated from a default of 2 mL water (adjustable).
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Frequently asked questions
How is lyophilised HCG stored?
Cited storage for the lyophilised vial: 20-25 °C (controlled room temperature) before reconstitution, per the US prescribing label..
How long is reconstituted HCG kept?
The cited reconstituted stability figure is 60 days [6].
What is the regulatory status of HCG?
US labels (DailyMed) for hCG products Novarel (Initial U.S. Approval 1974) and Pregnyl: Rx gonadotropin; label says not shown effective for obesity. Checked 2026-10-20.
Compound facts
What is the molecular weight of HCG?
What is the CAS number of HCG?
How is HCG stored in the laboratory?
Sources
- PubMed IDs
- 15713727, 20484472
References
Numbered sources used on this page. Markers in the text link here.
- dailymed.nlm.nih.gov Approved label
- dailymed.nlm.nih.gov Approved label
- Ovidrel (choriogonadotropin alfa, recombinant hCG, EMD Serono) US label (DailyMed) dailymed.nlm.nih.gov Approved label
- J Clin Endocrinol Metab 2005 (doi 10.1210/jc.2004-0802), randomized pubmed.ncbi.nlm.nih.gov Human trial
- J Clin Endocrinol Metab 2010 (doi 10.1210/jc.2010-0360), randomized pubmed.ncbi.nlm.nih.gov Human trial
- dailymed.nlm.nih.gov Approved label
Vial sizes and protocols
5,000 IUPartner size
10,000 IUPartner size
Available from Pepcore
Supplied as research material for laboratory use only.
Label figures describe the approved branded products. The research materials listed on this page are not approved drugs and are not evaluated by any regulator.
- HCG Research Material - 5,000 IU / 10,000 IU 5,000 IU$68.99Shop at PepcoreCoupon code
LAUNCH20 - HCG Research Material - 5,000 IU / 10,000 IU 10,000 IU$82.99Shop at PepcoreCoupon code
LAUNCH20
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